Harnessing good fats to relieve multiple sclerosis symptoms

Harnessing good fats to relieve MS symptoms
Endocannabinoids (eCBs) influence T-cells. A, structures of non-eCB epoxydocosahexaenoic acid (19,20-DHA-epoxide) and eCBs docosahexaenoyl ethanolamide (DHEA) and epoxydocosahexaenoyl ethanolamide (19,20-DHEA-epoxide). B, eCBs DHEA and DHEA-epoxide, but not non-eCB DHA-epoxide (19,20-), inhibits interferon gamma (IFNγ) production in TCRMOG splenocytes without toxicity as measured by lactate dehydrogenase (LDH). For IFNγ measurements, there were n = 9 mice per treatment, obtained from three independent n = 3 mice per treatment experiments. The LDH assay is from n = 3 mice from one experiment. C, schematic of DHEA or DHEA-epoxide treatment on T-cell polarization to Th1 and Th17 and gating strategy. D, effects of eCB treatment during naïve T-cell to Th1 or (E) Th17 polarization. One-way ANOVA and Tukey’s multiple comparisons test performed. MOG, myelin oligodendrocyte glycoprotein; TCR, T-cell receptor. Credit: Journal of Biological Chemistry (2023). DOI: 10.1016/j.jbc.2023.102886

Basic nutrition teaches that fat, when consumed in large quantities, is harmful to human health. However, the components that make up fats are complex. Good, unsaturated fats, or lipids, can lower disease risk. In fact, in a new study, researchers found that a good fat derivative may be able to relieve symptoms in patients suffering from chronic inflammatory diseases, such as multiple sclerosis (MS). They published their results in the Journal of Biological Chemistry on Jan. 7.

The study was conducted by Justin Kim, a postdoctoral fellow at the Georgia Institute of Technology, Aditi Das, an associate professor of chemistry and biochemistry at Georgia Tech, Andrew Steelman, an associate professor of animal sciences at the University of Illinois at Urbana-Champaign, and their colleagues.

MS is a chronic, autoimmune of the brain and spinal cord during which the attacks the cells and tissues that protect nerve fibers. This potentially debilitating disease can cause pain, , fatigue, impaired cognitive function and more. There is no cure for MS, and it affects almost 1 million people nationwide.

The researchers specifically looked at docosahexaenoyl ethanolamide (DHEA), a derivative of the lipids found in cold-water fish and fish , and its impact on the immune system. Interestingly, DHEA has been shown to be anti-inflammatory and has similar properties to cannabis in some contexts.

“Our goal was to use something that is naturally found in food and the human body to see if we can enhance it to reduce the disease severity in multiple sclerosis patients,” Das said.

Using a common mouse model that closely mimics the relapsing and remitting nature of MS, Kim, Steelman and Das noticed that DHEA is at its highest concentration in the mice when they are in a state of remission, which prompted them to consider if DHEA could dampen the inflammation that controls the disease.

“We thought if we could somehow alleviate, control or reduce the level of inflammation, we could improve the disease outcomes and severity,” Kim explained.

Even though taking fish oil supplements has been linked to improved quality of life in patients with inflammatory conditions, the interworking of this association has never been teased apart in MS, until now. Kim, Steelman and Das were the first to show that the DHEA lipid can reduce inflammation and disease signs in a mouse model of MS.

The researchers found that, when they supplemented the diet of mice with DHEA, the mice showed less severe and later onset of MS-like disease. This reduction is likely due to the presence of fewer activated, pathogenic T cells in the central nervous system, the research team found.

“We believe our findings could lead to the discovery of new solutions to aid in managing symptoms of multiple sclerosis and other like diabetes,” Das said.

So, should you start taking fish oil supplements? First, more work is needed to study how DHEA affects other parts of the immune system and humans. However, the researchers are optimistic that this is a step forward in using naturally occurring good fats or their derivatives to lower inflammation without the negative side effects of some currently prescribed medications.

“I’ve seen that a lot of patients with multiple sclerosis are fully in tune with the research,” Kim said. “They are always trying to do everything that they can to improve their symptoms, whether it be through exercise, diet or just healthy living, while trying to reduce their consumption of heavy pain medications.”

The National Multiple Sclerosis Society advises patients reasonable doses of fish oil and omega-3 fatty acid supplements are generally safe and may be beneficial. However, patients should consult with their doctors before changing their medications, and supplements should never be used as a replacement for conventional therapies.

“There is no cure for MS, yet, and anything to help improve the patients’ symptoms is always of interest,” Kim said.

More information:
Justin S. Kim et al, Role of omega-3 endocannabinoids in the modulation of T-cell activity in a multiple sclerosis experimental autoimmune encephalomyelitis (EAE) model, Journal of Biological Chemistry (2023). DOI: 10.1016/j.jbc.2023.102886

Harnessing good fats to relieve multiple sclerosis symptoms (2023, February 8)
retrieved 8 February 2023
from https://medicalxpress.com/news/2023-02-harnessing-good-fats-relieve-multiple.html

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